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Abstract #11285 Published in IGR 6-3
Review of the ischemia hypothesis for ocular hypertension other than congenital glaucoma and closed-angle glaucoma
Nakabayashi MOphthalmologica 2004; 218: 344-349
Experimentally induced ischemia of the endothelial cells surrounding the aqueous drainage sites led to a rise in intraocular pressure (IOP) in monkey and pigeon eyes. Clinical conditions associated with a rise in IOP in human eyes, e.g. peripheral retinal detachments, subluxated lenses, and occlusion of the internal carotid artery, can result in ischemia of the endothelial cells lining Schlemm's canal. These findings led to the hypothesis that ischemia of the endothelial cells of Schlemm's canal induces hypertension in human eyes. Thus, the ischemia hypothesis should be considered in discussions of the etiology of age-related open-angle glaucoma.
Dr. M. Nakabayashi, Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
2.5.2 Schlemms canal (Part of: 2 Anatomical structures in glaucoma > 2.5 Meshwork)
