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Abstract #11339 Published in IGR 6-3
The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study
Iwase A; Suzuki Y; Araie M; Yamamoto T; Abe H; Shirato S; Kuwayama Y; Mishima HK; Shimizu H; Tomita GOphthalmology 2004; 111: 1641-1648
PURPOSE: To assess the prevalence of primary open-angle glaucoma (POAG) and its association with intraocular pressure (IOP) in Tajimi City in central Japan. DESIGN: A cross-sectional epidemiologic study in a defined population. PARTICIPANTS: Subjects randomly selected from the population older than 40 years in Tajimi City. INTERVENTION: Each subject underwent a screening examination comprised of an interview and ophthalmic examinations, including measurement of IOP by a Goldmann applanation tonometer, central corneal thickness (CCT), slit-lamp examination, fundus photography, and a screening visual field test using frequency doubling technology. When ocular diseases were suspected, the subjects were referred for definitive examination. During the definitive examination, slit-lamp examination, IOP measurement, a visual field test using Humphrey Field Analyzer 30-2 SITA Standard program (Humphrey Instruments, San Leandro, CA), optic disc and fundus examination, and gonioscopy were performed and stereoscopic disc photographs were obtained. A diagnosis of glaucoma was made based on optic disc appearance, perimetric results, and other ocular findings. MAIN OUTCOME MEASURES: Prevalence of POAG, mean IOP, and mean CCT. RESULTS: Of 3870 eligible people, 3021 (78.1%) participated in the study. The estimated prevalence of POAG in the population older than 40 years was 3.9% (95% confidence interval [CI]), 3.2%-4.6%). The prevalence of cases of POAG with IOP levels of 21 mmHg or less was 3.6% (95% CI, 2.9%-4.3%), whereas the prevalence for those with IOP levels of more than 21 mmHg was 0.3% (95% CI, 0.1%-0.5%). The average IOP for eyes with POAG was 15.4± 2.8 (standard deviation) in the right eye (n = 115) and 15.2 ± 2.8 mmHg in the left eye (n = 115), which was significantly higher than that of nonglaucoma subjects (14.5 ± 2.5 in the right eye; n = 2759; P = 0.0004; and 14.4 ± 2.6 mmHg in the left eye; n = 2757; P = 0.0026). The mean CCT of POAG eyes with IOP levels of 21 mmHg or less was 518 ± 29 (n = 109) in the right eye and 519 ± 29 μm (n = 110) in the left eye, levels that were not significantly different from that of nonglaucoma eyes (520 ± 32 μm [n = 2690]; and 522 ± 32 μm [n = 2692]; p > 0.05). CONCLUSIONS: The prevalence of POAG in this population was 3.9%. In 92% patients with POAG, the IOP was 21 mmHg or less.
Dr. A. Iwase, Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
Classification:
1.1 Epidemiology (Part of: 1 General aspects)
