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1 General aspects (0)   1.1 Epidemiology (6)   1.2 Population genetics (0)   1.3 Pathogenesis (4)   1.4 Quality of life (6)   1.5 Glaucomas as cause of blindness (1)   1.6 Prevention and screening (3) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (3)   2.2 Cornea (5)   2.3 Sclera (2)   2.4 Anterior chamber angle (2)   2.5 Meshwork (1)     2.5.1 Trabecular meshwork (8)     2.5.2 Schlemms canal (2)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (2)     2.6.2 Outflow (4)       2.6.2.1 Trabecular meshwork (0)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (1)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (0)   2.9 Ciliary body (0)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (1)   2.13 Retina and retinal nerve fibre layer (11)   2.14 Optic disc (9)   2.15 Optic nerve (4)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (0) 3 Laboratory methods (10)   3.1 Microscopy (1)   3.2 Electron microscopy (5)   3.3 Immunohistochemistry (9)   3.4 Molecular genetics (1)     3.4.1 Linkage studies (16)     3.4.2 Gene studies (2)   3.5 Molecular biology incl. 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Abstract #11484 Published in IGR 6-3

Effect of ocular hypotensive medications in preventing the progression of visual field damage in patients with normal-tension glaucoma

Nakagami T; Yamazaki Y; Hayamizu F; Tanaka C
Nippon Ganka Gakkai Zasshi 2004; 108: 408-414

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PURPOSE: We investigated the effect of ocular hypotensive medications and the risk factors for progression of visual field damage in patients with normal-tension glaucoma (NTG). SUBJECTS AND METHODS: Sixty-four NTG patients (64 eyes) followed at least 4 years with ocular hypotensive medications were studied regarding the probability of visual field stability using the Kaplan-Meier life-table analysis and multiple regression analysis with the Cox proportional hazards model. RESULTS: Probability of visual field stability was 56% at the 76-month follow-up. Mean intraocular pressure during the follow-up period and generalized cup enlargement type classified according to the optic disc shape were found to have significant influence on the progression of visual field damage. CONCLUSION: These findings suggest that ocular hypotensive medications are effective in stabilizing the visual field. We need to pay attention to the optic disc shape in patients with NTG. LA: Japanese

Dr. T. Nakagami, Department of Ophthalmology, Nihon University School of Medicine, Tokyo Japan

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Classification:

11.1 General management, indication (Part of: 11 Medical treatment)

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