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Abstract #11557 Published in IGR 6-3
The mechanism of ocular hypotensive effect of CS-088, angiotensin II type I receptor blocker, in pigmented rabbit - Investigation of central ocular hypotensive effect
Yoshida M; Ueda T; Noda T; Shimada S; Koide R; Shi Yu G; Hisamitsu T; Oguchi KJournal of the Showa Medical Association 2004; 64: 199-205
The central effects of CS-088, angiotensin II type 1 receptor blocker on intraocular pressure (IOP) in male pigmented rabbits were investigated. Fifty μL CS-088 was administered to the lateral eye, orally, or intravenous by from the auricular vein (i.v.). For intracerebroventricular (icv) treatment, a guide cannula was inserted two weeks before injection into the lateral ventriulus following Fifkova's brain map; ten μL CS-088 was subsequently injected (5 μL/min) to the lateral ventriculus. After the treatments, IOP was measured with a pneumatonometer and blood pressure (BP) at the right lower limb was monitored without anesthesia. IOPs were significantly decreased bilaterally after 30 min topical administration of 6% CS-088 to the lateral eye compared to a phosphate buffer treatment of the control group (p < 0.05, n = 6); BP showed no change. With 6% CS-088 oral administration, IOP and BP were not changed. IOP and BP decreased significantly at 60 min after 6% CS-088 i.v. treatment (p < 0.05, n = 5). IOP did not change with 0.06% CS-088 icv treatment. These results suggest that topical use of CS-088 might decrease IOP in the pigmented rabbit by a sympathetic nerve effect and its local effect. LA: Japanese
Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
