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Abstract #116993 Published in IGR 24-4
Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis
Pan L; Wu J; Wang NGenes 2024; 15:
BACKGROUND: Normal tension glaucoma (NTG) is becoming a more and more serious problem, especially in Asia. But the pathological mechanisms are still not illustrated clearly. We carried out this research to uncover the gene polymorphisms with NTG. METHODS: We searched in Web of Science, Embase, Pubmed and Cochrane databases for qualified case-control studies investigating the association between single nucleotide polymorphisms (SNPs) and NTG risk. Odds ratios (ORs) and 95% confidence intervals (CIs) for each SNP were estimated by fixed- or random-effect models. Sensitivity analysis was also performed to strengthen the reliability of the results. RESULTS: Fifty-six studies involving 33 candidate SNPs in 14 genetic loci were verified to be eligible for our meta-analysis. Significant associations were found between 16 SNPs (rs166850 of ; rs10451941 of ; rs735860 of ; rs678350 of ; c.603T>A/Met98Lys of ; c.412G>A/Thr34Thr of ; rs10759930 of ; rs1927914 of ; rs1927911 of ; c.*70C>G of ; rs1042522/-Arg72Pro of ; rs10483727 of ; rs33912345 of ; rs2033008 of ; rs3213787 of and c.231G>A of ) with increased or decreased risk of NTG. CONCLUSIONS: In this study, we confirmed 16 genetic polymorphisms in 10 genes (, , , , , , , , and ) were associated with NTG.
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, No. 1 Dong Jiao Min Xiang Street, Dongcheng District, Beijing 100730, China.
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