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Abstract #117246 Published in IGR 24-4
Higher vitamin B dietary consumption is associated with a lower risk of glaucoma among United States adults
Yang Z; Zhang J; Zheng YFrontiers in nutrition 2024; 11: 1363539
OBJECTIVE: Although numerous studies have substantiated the neuroprotective effects of vitamin B on the optic nerve and its enhancement of visual function, comprehensive data delineating the correlation between vitamin B and glaucoma at a national demographic scale remain insufficient. This study is designed to explore the link between the dietary consumption of vitamin B and glaucoma. METHODS: This study included 3,850 individuals aged 40 and older from the National Health and Nutrition Examination Survey (NHANES), spanning 2005-2008. Dietary consumption of vitamin B was calculated from the average of two 24-h dietary recall interviews. Glaucoma was diagnosed in accordance with the established Rotterdam criteria. To evaluate the relationship between vitamin B dietary consumption and the risk of glaucoma, we employed Restricted Cubic Splines and weighted multivariable logistic regression analysis. We employed stratified and three other sensitivity analyses to confirm the robustness of our results, and conducted a preliminary exploration of the potential association between vitamin B supplement consumption and glaucoma risk. RESULTS: After adjusting for covariates, we found a significant inverse correlation between dietary consumption of vitamin B and glaucoma risk ( = 0.18; for trend = 0.02). Stratified analysis and three other sensitivity analyses revealed stability in the outcomes (all p for interaction>0.05). Compared to the lowest quartile of consumption (≤1.23 mg/day), individuals in the highest quartile of vitamin B consumption (>2.34 mg/day) experienced a 75% reduction in glaucoma risk (OR = 0.25, 95% CI 0.07-0.92). However, the effect of vitamin B supplements on glaucoma was inconclusive. CONCLUSION: A diet high in vitamin B inversely correlates with glaucoma risk, suggesting that increasing dietary intake of vitamin B could be a viable preventative strategy against glaucoma among adults in the United States.
Department of Ophthalmology, The Second Hospital of Jilin University, Jilin University, Changchun, China.
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