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Abstract #117247 Published in IGR 24-4
Association of plasma lactoferrin levels with disease severity in glaucoma patients
Wang Z; Liu D; Yuan H; Li A; Wang J; Zhu X; Xiu W; Zhang G; Chen Y; Chen L; Xiao X; He C; Lu FFrontiers in medicine 2024; 11: 1385358
OBJECTIVE: To explore the relationship between plasma lactoferrin (Lf) and glaucoma, assessing the clinical utility of Lf in glaucoma. METHODS: A cross-sectional study involved 161 glaucoma patients and 115 healthy controls, with a follow-up of 14 subjects after approximately 2 years. Plasma Lf markers were quantified using ELISA, comparing levels between glaucoma patients and healthy controls, and analyzing plasma Lf across different glaucoma severity grades. RESULTS: Glaucoma patients had significantly elevated plasma Lf levels compared to healthy controls ( < 0.001). Higher plasma Lf levels correlated with more severe disease stages (HPA grades showed = 0.435, < 0.001; AGIS grades showed = 0.436, < 0.001) and reduced retinal nerve fiber layer (RNFL) thickness (RNFL thickness showed = -0.204, = 0.024). ROC curve analysis demonstrated the efficacy of glaucoma markers in differentiating early-stage from advanced glaucoma. CONCLUSION: Plasma Lf levels are significantly associated with glaucoma severity and may be involved in the pathogenic progression of the disease.
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