advertisement
Abstract #11732 Published in IGR 7-1
Medical control of intraocular pressure after phacoemulsification
Dayanir V; Ozcura F; Kir E; Topaloglu A; Ozkan SB; Aktunc TJournal of Cataract and Refractive Surgery 2005; 31:484-488
PURPOSE: To compare the effectiveness of oral acetazolamide, topical brinzolamide 1%, and no ocular hypotensive medication after phacoemulsification. SETTING: Adnan Menderes University Department of Ophthalmology, Aydin, Turkey. METHODS: This prospective randomized double-blind study comprised 60 eyes of 52 patients having phacoemulsification under topical anesthesia. There were no intraoperative complications. Eyes were randomized to receive oral acetazolamide 500 mg 1 hour preoperatively followed by 250 mg acetazolamide every 6 hours, 1 drop of brinzolamide 1% every 12 hours starting immediately after speculum removal, or no ocular hypotensive medication. Intraocular pressure (IOP) was measured using a Perkins tonometer preoperatively and 4 to 6 hours and 18 to 24 hours postoperatively. RESULTS: The preoperative IOP was not significantly different between the 3 groups. Four to 6 hours postoperatively, the acetazolamide group (P = .002) and brinzolamide group (P = .001) had significantly lower IOP than the control group. The same trend was observed at 18 to 24 hours in the brinzolamide group (P = .001) but not the acetazolamide group (P = .018). The IOP levels were not significantly different between the acetazolamide group and brinzolamide group at any postoperative time point. No eye receiving medication and 2 eyes (10%) in the control group had an IOP of 30 mmHg or higher 4 to 6 hours postoperatively. Compared with preoperatively, an IOP increase of more than 5 mmHg was seen at 4 to 6 hours in 3 eyes (15%), 2 eyes (10%), and 14 eyes (70%) in the acetazolamide, brinzolamide, and control group, respectively. CONCLUSION: Brinzolamide was as effective as acetazolamide in preventing IOP elevation 4 to 6 hours after phacoemulsification and more effective than acetazolamide at 18 to 24 hours.
Dr. V. Dayanir, Department of Ophthalmology, School of Medicine, Adnan Menderes University, Aydin, Turkey.
Classification:
12.14.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.14 Combined cataract extraction and glaucoma surgery)
