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Abstract #11794 Published in IGR 7-1
The comparison of topical ibopamine 2% with tonography to identify the outflow resistance in eyes with ocular hypertension
Hepsen IF; Yilmaz H; Keskin UCOphthalmic Research 2004; 37: 17-22
BACKGROUND: To evaluate the ability of topical ibopamine 2% to detect outflow resistance by comparing it with the tonography test in eyes with ocular hypertension (OHT). METHODS: 62 eyes with OHT and 33 control eyes were included in this prospective study. Tonography was done manually as a standard outflow facility measurement. We used a C value of 0.18 μl/min/mmHg or less and a Po /C value of 100 and above as a positive tonographic test. The ibopamine test performed on the following day was considered positive if there was an intraocular pressure (IOP) change of at least 3 mmHg. RESULTS: The sensitivity of the tonography and ibopamine tests as 69 and 53%, respectively, in eyes with OHT. The specificity of both tests was 97%. Although the sensitivity of the tonography test is higher than that of the ibopamine test, the difference between both was not statistically significant in these eyes (p = 0.409). Positive results in tonography were associated with higher IOP, while the results were not dependent on the IOP in the ibopamine test. Both tests together were positive in 33.87% (21 eyes) and negative in 11.29% (7 eyes) in 62 eyes with OHT. CONCLUSION: This study revealed that the ibopamine provocation test can detect outflow system resistance in eyes with OHT comparable with tonography which is a traditional outflow facility measurement. Ibopamine, however, can detect the eye with outflow impairment by a different and IOP-independent way, while tonography depends on IOP.
Dr. I.F. Hespen, Department of Ophthalmology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey
Classification:
6.2 Tonography, aqueous flow measurement (see also 2.6) (Part of: 6 Clinical examination methods)
6.13 Provocative tests (Part of: 6 Clinical examination methods)
