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Abstract #118110 Published in IGR 24-4
In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery
Gniesmer S; Gniesmer S; Sonntag SR; Sonntag SR; Gapeeva A; Gapeeva A; Cojocaru A; Cojocaru A; Kaps S; Kaps S; Adelung R; Adelung R; Sewing J; Tura A; Grisanti SScientific reports 2024; 14: 4452
To carry out the preclinical and histological evaluation of a novel nanotechnology-based microshunt for drainage glaucoma surgery. Twelve New Zealand White rabbits were implanted with a novel microshunt and followed up for 6 weeks. The new material composite consists of the silicone polydimethylsiloxane (PDMS) and tetrapodal Zinc Oxide (ZnO-T) nano-/microparticles. The microshunts were inserted ab externo to connect the subconjunctival space with the anterior chamber. Animals were euthanized after 2 and 6 weeks for histological evaluation. Ocular health and implant position were assessed at postoperative days 1, 3, 7 and twice a week thereafter by slit lamp biomicroscopy. Intraocular pressure (IOP) was measured using rebound tonometry. A good tolerability was observed in both short- and medium-term follow-up. Intraocular pressure was reduced following surgery but increased to preoperative levels after 2 weeks. No clinical or histological signs of inflammatory or toxic reactions were seen; the fibrotic encapsulation was barely noticeable after two weeks and very mild after six weeks. The new material composite PDMS/ZnO-T is well tolerated and the associated foreign body fibrotic reaction quite mild. The new microshunt reduces the IOP for 2 weeks. Further research will elucidate a tube-like shape to improve and prolong outflow performance and longer follow-up to exclude medium-term adverse effects.
Department of Ophthalmology, University of Luebeck, Luebeck, Germany. stefanie.gniesmer@uksh.de.
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