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Abstract #11838 Published in IGR 7-1
Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study
Klein BE; Klein R; Knudtson MDBritish Journal of Ophthalmology 2005; 89: 284-287
See also comment(s) by Erik Greve •
AIM: To investigate the relation between change in systemic blood pressures and change in intraocular pressure. METHODS: This was a population based study of people 43-86 years old living in Beaver Dam, Wisconsin. Measurements at baseline (1988-90) and 5 year follow up of systemic blood pressures, intraocular pressures, and history of use of blood pressure medications. RESULTS: Intraocular pressures were significantly correlated with systolic and diastolic blood pressures at both baseline and follow up. There were significant direct correlations between changes in systemic blood pressures and changes in intraocular pressure. There was a 0.21 (95% CI: 0.16 to 0.27) mmHg increase in IOP for a 10 mmHg increase in systolic and 0.43 (0.35 to 0.52) mmHg increase in IOP for a 10 mmHg increase in diastolic blood pressure. Further adjustment for diabetes and medication use did not alter these associations. Decreased systolic or diastolic blood pressures of more than 10 mmHg over 5 years were significantly associated with decreased IOP. CONCLUSIONS: Reduced systemic blood pressure is associated with reduced intraocular pressure. This finding should be evaluated in other studies, especially with respect to the possibility of resultant decreased risk of open angle glaucoma.
Dr. B.E. Klein, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53726-2336, USA. kleinb@epi.ophth.wisc.edu
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
