advertisement
Abstract #118418 Published in IGR 24-4
The long-term effects of topical latanoprost 0.005% treatment on pupillary functions: A 2-year longitudinal study
Bayraktar S; Hondur G; Şekeroğlu MA; Cengiz Özyurt B; Şen E; Şen EEuropean Journal of Ophthalmology 2024; 0: 11206721241227780
PURPOSE: To investigate the long-term effects of topical latanoprost 0.005% treatment on pupillary functions in early-stage primary open-angle glaucoma (POAG) eyes using automated pupillometry. METHODS: This prospective study involved 20 eyes of 20 treatment-naive subjects with early-stage POAG. After comprehensive ophthalmic examination, static and dynamic pupillometry measurements were performedbefore treatment, at the 1st follow-up visit (1.10 ± 0.30 months) and the 2nd follow-up visit (25.85 ± 10.26 months) after treatment initiation. Dynamic parameters included resting diameter (mm), amplitude (mm), latency (ms), duration (ms), and velocity (mm/s) of pupil contraction and dilation. Static pupillometry parameters were pupil diameter (PD, mm) in high-photopic, low-photopic, mesopic and scotopic conditions. RESULTS: The velocity of pupil dilation significantly decreased during the 1st visit ( = 0.008) and the 2nd visit ( = 0.0003) of treatment compared to the pre-treatment visit. The resting PD was also significantly higher after the 1st visit ( = 0.003) and the 2nd visit ( = 0.001) compared to the pre-treatment visit. However, the difference in resting PD measured between the 1st and 2nd visits did not reach statistical significance ( = 0.065). There were no significant changes in other dynamic parameters ( > 0.05 for all). Additionally, a mild, but not significant, mydriatic effect was observed in PD measurements under scotopic, mesopic and low photopic lighting conditions after follow-up. None of the static and dynamic parameters correlate with age, changes in intraocular pressure (IOP) or mean deviation (MD) values of visual field tests. CONCLUSION: The long-term topical latanoprost 0.005% treatment in early-stage POAG has a slight mydriatic effect on the pupil. Further longitudinal clinical studies with larger patient cohorts are necessary to better understand the effects of latanoprost on pupillary functions.
Department of Ophthalmology, The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Full article