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Abstract #118669 Published in IGR 24-4
A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction
Takahashi N; Sato K; Kiyota N; Tsuda S; Murayama N; Nakazawa TScientific reports 2023; 13: 22715
The aim of this study was to investigate the effect of a ginger extract on optic nerve head blood flow (ONH BF) under endothelin-1 (ET-1) stimulation. Using laser speckle flowgraphy, we measured ONH BF in brown Norway rats. To establish the ONH BF impairment profile under ET-1 stimulation, we administered an intravitreal injection of ET-1 under anesthesia. We then gave the ginger extract sublingually to assess its effect on ONH BF in both normal and ET-1-induced ischemic conditions. Post ET-1 injection, there were no significant changes in parameters including intraocular pressure or systemic factors. ONH BF showed a dose-dependent decline after ET-1 injection, with a significant reduction after a 2.50 pmol ET-1 dose. Sublingual administration of the ginger extract significantly improved ONH BF in both normal and ET-1-stimulated rats. This suggests that our newly developed supplement for improving ONH BF has a potential role in retinal ischemic diseases, including glaucoma.
Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo, Aoba, Sendai, Miyagi, 980-8574, Japan.
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