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Abstract #11969 Published in IGR 7-1

Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity

Schuettauf F; Vorwerk C; Naskar R; Orlin A; Quinto K; Zurakowski D; Dejneka NS; Klein RL; Meyer EM; Bennett J
Current Eye Research 2004; 29: 379-386

See also comment(s) by Leonard A. Levin •

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PURPOSE: Brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (bFGF) hold much promise for the protection of retinal ganglion cells against excitotoxic cell death. We tested the possibility of delivering these growth factors to retinal ganglion cells via an adeno-associated viral (AAV) vector and tested their efficacy in two models of excitotoxicity. METHODS: Rat retinas were infected with AAV vectors encoding bFGF or BDNF. A control vector containing green fluorescent protein (GFP) was injected in the contralateral eye. Eyes were subjected to either an intravitreal injection of N-methyl-D-aspartate (NMDA) or optic nerve crush, and ganglion cell survival was evaluated. RESULTS: AAV.CMV.bFGF and AAV.CBA.BDNF were neuroprotective against NMDA injection 1 month post-treatment. Additionally, AAV.CMV.bFGF was protective against optic nerve crush. CONCLUSION: AAV-mediated delivery of bFGF and BDNF can promote retinal cell survival following excitotoxic insult.

Dr. F. Schuettauf, Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute, Philadelphia, Pennsylvania, USA. fschuettauf@uni-tuebingen.de

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Classification:

11.8 Neuroprotection (Part of: 11 Medical treatment)

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