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Abstract #12052 Published in IGR 7-1
Nitric oxide level of serum and aqueous humor in glaucoma patients
Chu Y; Shen J; Kang RChinese Ophthalmic Research 2004; 22: 650-652
OBJECTIVE: To detect the nitric oxide (NO) level of serum and aqueous humor in glaucoma patients and study its possible role in the pathogenesis of glaucoma. METHODS: Forty-two patients (84 eyes) were divided into glaucoma group and control group. The glaucoma group included primary open-angle glaucoma (POAG), primary chronic angle-closure glaucoma and primary acute angle-closure glaucoma. NO levels in serum and aqueous humor were detected by NO reductase method. RESULTS: There was an insignificant difference of NO level in serum between the glaucoma group and the control group, and the difference was also seen among different types of glaucoma. The NO level of aqueous humor in POAG group was significantly lower than that of the control group and was significantly higher in the angle-closure glaucoma in comparison with the control group. CONCLUSION: Elevation of intraocular pressure induces the increase of NO level in aqueous humor and further damages the trabecular meshwork, adjacent uvea and retina. For the POAG patients, decrease of NO synthetase in anterior chamber angle can induce decrease of NO in aqueous humor resulting in higher outflow resistance of aqueous humor. LA: Chinese
Dr. Y. Chu, Shandong Provincial Hospital, Jinan 250021, China
Classification:
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
