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Abstract #12199 Published in IGR 7-2
Incidence and profile of latanoprost nonresponders
Inoue K; Izumi M; Wakakura M; Inouye J; Tomita GJapanese Journal of Clinical Ophthalmology 2005; 59: 553-557
We evaluated the rate of intraocular pressure reduction in 88 eyes of 88 patients who received latanoprost intillation once daily. The series comprised 22 cases of primary open-angle glaucoma, 43 cases of normal tension glaucoma, and 23 cases of ocular hypertension. The intraocular pressure (IOP) averaged 19.4 ± 3.3 mmHg before start of instillation, 15.3 ± 3.4 mmHg after 1 month, 14.9 ± 3.3 mmHg after 3 months, and 14.7 ± 2.9mmHg after 6 months. The IOP reduction was significant (p < 0.0001), with the rate of IOP reduction ranging from 20.2% to 23.5%. IOP before start of instillation was the sole significant factor related to the rate of IOP reduction (p = 0.0019, R2 = 0.20). Latanoprost responder was defined as those manifesting less than 10% of IOP reduction. Its incidence was 20.9% at 1 month, 18.2% at 3 months, and 14.3% at 6 months of instillation. Latanoprost nonresponders were more frequent among those with low IOP before start of instillation. LA: Japanese
Dr. K. Inoue, Inouye Eye Hospital, 4-3 Kanda-Surugadai, Chiyoda Tokyo 101-0062, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
