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Abstract #12230 Published in IGR 7-2
Comparative evaluation of effect of rocuronium and succinylcholine on intraocular pressure
Malik P; Rao S; Malhotra N; Chugh JP; Hooda SJournal of Anaesthesiology Clinical Pharmacology 2004; 20: 255-261
The present study was conducted in 60 patients of either sex, in the age group of 20-60 years to compare the effect of rocuronium and succinylcholine on intraocular pressure. The patients were randomly allocated to two groups of 20 each. In group I, patients received succinylcholine 1.5mgkg-1 and in group II rocuronium 0.9mgkg-1 for tracheal intubation. Intubating conditions and haemodynamic changes were comparable in between the groups (p > 0.05). There was a significant increase in intraocular pressure with the administration of succinylcholine which further increased after tracheal intubation and remained elevated upto five minutes after tracheal intubation (p < 0.001). With rocuronium, there was a significant decrease in intraocular pressure and it remained lower than the baseline in the post intubation period (p < 0.001). We concluded that rocuronium in a dose of 0.9mgkg-1 provides good to excellent intubating conditions comparable to that of succinylcholine and is a suitable agent for tracheal intubation in patients undergoing elective and emergency ophthalmic surgery where rise in intraocular pressure is undesirable.
Dr. N. Malhotra, Dept. Anaesthiol./Critical Care/O., Pt. B.D.S. PGIMS, Rohtak (Haryana), India
Classification:
11.17 Cooperation with medical therapy e.g. persistency, compliance, adherence (Part of: 11 Medical treatment)