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Abstract #12248 Published in IGR 7-2
Changes of physiological intraocular pressure (IOP) in rabbits after amino acid lysine with antiglaucomatic drug latanoprost (Xalatan)
Olah Z; Veselovsky J; Gressnerova S; Vesela AČeska a Slovenska Oftalmologie 2005; 61: 147-153
PURPOSE: To show and underline specific character of influence of the mixture of 10% L-lysine.2HCl.2H2 O in 0.005% latanoprost on physiological levels of IOP. METHODS: The mixture of 10% L-lysine.2HCl.2H2 O in 0.005 % latanoprost (Xalatan), or separately 0.005% latanoprost and 10% L-lysine.2HCl.2H2 O respectively were in weekly intervals instilled into the conjunctival sac of the left eye of five rabbits (females of New Zealand white bred). The IOP levels and the size of the pupil were measured in minute 5, 15, 30, 60, 120, 180, and 240 after the instillation. The right eye was considered as a control. RESULTS: The amino acid L-lysine.2HCl.2H2 O by itself did not influence the IOP or the size of the pupil; latanoprost until minute 30 lowered the IOP, in minute 55 exceeds the IOP the level of the control eye. Since minute 60 until 240, the IOP changed irregularly and insignificantly. The mixture of 10% solution of L-lysine.2HCl.2H2 O in latanoprost 0.005% insignificantly lowered the IOP until min. 30, after rapid elevation in min. 50 exceeds the IOP of the control eye, and since min. 60, the IOP remains above the control eye's IOP with the same course of levels. SUMMARY: The amino acid L-lysine.2HCl.2H2 O alone did not change the physiological IOP. Latanoprost 0.005% significantly lowered the IOP until min 30. High level of interactive specificity as well as duration of influence of the mixture of respective amino acid with respective antiglaucomatic drug was established. LA: Slovak
Dr. Z. Olah, Klinika Oftalmologie LF UK, Mickiewiczova 13, 913 69 Bratislava, SR, Slovakia
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)