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Abstract #12281 Published in IGR 7-2
Comparative effect of timolol, levobunolol and betaxolol on IOP in patients of chronic simple glaucoma
Sharma R; Kohli K; Kapoor B; Mengi RK; Sadotra P; Verma UJK Science 2005; 7: 77-80
In this prospective randomized parallel study we compared the effects of topical timolol maleate, levobunolol hydrochloride and betaxolol hydrochloride on intraocular pressure (IOP) in the patients of primary open angle glaucoma after 16 weeks of instillation as 1 drop 12 hourly in 0.5% concentration. 23 eyes of 16, 19 eyes of 12 and 20 eyes of 12 patients were included in timolol, levobunolol and betaxolol groups respectively. Timolol, levobunolol and betaxolol lowered IOP by 13.05 ± 1.53, 14.05 ± 1.47 and 7.58 ± 0.90 mmHg respectively after 6weeks and by 16.12 ± 1.67, 16.28 ± 1.85 and 8.535 ± 0.983 mmHg respectively after 16 weeks (P < 0.001). Both levobunolol and timolol produced greater reduction in IOP than betaxolol (P < 0.001). The results of our study indicated that betaxolol is less efficacious in lowering IOP in Indian patients and could only be preferred over timolol in glaucoma patients with associated chronic obstructed pulmonary disease (COPD) or bronchial asthma. However, Levobunolol could be a better alternative to timolol, as being a longer acting agent with IOP control for 24 hrs after single instillation and can be used as once a day instillation with better safety profile.
Dr. R. Sharma, Postgraduate Department of Pharmacology and Therapeutics, Govt. Medical College, Jammu, India
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
