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Abstract #12314 Published in IGR 7-2
Application of mitomycin C in non-perforating trabecular surgery in 32 cases
Zhang X; Liang C-L; Xu Y; Guo S-PInternational Journal of Ophthalmology 2005; 5: 107-111
AIM: To evaluate the clinical effects of nonperforating trabecular surgery (NPTS) with application of mitomycin C (MMC), and to observe the appearance of ultrasound biomicroscopy (UBM). METHODS: Thirty-two cases (44 eyes) of advanced open angle glaucoma underwent NPTS with application of MMC. Post-operatively, the intraocular pressure (IOP), best correct visual acuity and bleb appearance were recorded, and UBM was performed at 3 and 6mo. RESULTS: The follow-up lasted for 6-18mo. The mean IOP was (34.64 ± 8.37) mmHg pre-operatively and (13.63 ± 3.64) mmHg post-operatively. On the latest visit, the IOP was ≤ 21 mmHg in all eyes (100%), among which there were 4 eyes (9%) using only one anti-glaucoma medicine and the other 40 eyes (91%) without anti-glaucoma medicine. Two eyes underwent a second-operation 2wk after the first operation due to the scarification of the sub-conjunctival tissue. The IOP of 1 eye was < 21 mmHg, and was < 21 mmHg in the other eyes after applying Timolol (5g/L). There were no flare or cells in the anterior chamber in 35 eyes. In 4 eyes there was only slight flare that disappeared in 2d. Hyphema was found in 5 eyes 1d after operation due to sneezing in 1 eye. All the hyphema was absorbed in 4-7d. Post-operatively, there was an obvious diffuse bleb in each eye; at the latest visit, there were functional blebs in 39 eyes, and the filtration was ceased in 5 eyes within 1-3mo. In the post-operative 3 and 6mo, UBM was performed, 4 eyes had a narrow and long scleral cavity, and the other 40 eyes had an obvious scleral cavity. The biggest length was 1.56-3.2mm in these cavities. In contrast to other regions, apparently weaker echo area could be seen in the sub-conjunctival tissue that contributed to the bleb. Moreover, sub-conjunctival cavity sometimes can be seen. CONCLUSION: The elevated IOP in patients with open angle glaucoma can be effectively reduced by NPTS. The post-operative complications were much less because of non-penetration of the anterior chamber. Therefore, NPTS is an economical and effective anti-glaucoma surgery. LA: Chinese
Dr. X. Zhang, He Eye Hospital of Dalian City, Dalian 116023 Liaoning Province, China
Classification:
12.8.3 Non-perforating (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
