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Abstract #12357 Published in IGR 7-2
Efficacy and safety of bimatoprost in patients with uncontrolled glaucoma as alternative to filtration surgery
Vetrugno M; Sborgia C; Balestrazzi E; Bianchi C; Caporossi A; Nardi M; Rapisarda A; Tassinari G; Zeppa LEuropean Journal of Ophthalmology 2005; 15: 477-481
PURPOSE: To evaluate the efficacy and safety of bimatoprost 0.03% as an alternative to filtration surgery in patients with uncontrolled glaucoma. DESIGN: Interventional study. METHODS: A total of 83 consecutive patients (83 eyes) awaiting glaucoma surgery were enrolled in eight ophthalmic centers. Reasons for listing were inadequate intraocular pressure (IOP) control despite medical therapy and documented progression of visual field loss. All patients discontinued the previous treatment and were switched to bimatoprost 0.03% QD (one drop at 9 pm). The primary efficacy outcome was a 20% IOP reduction from baseline at each timepoint. IOP was measured at day 7, day 30, day 60, and day 90 of treatment; less than 20% IOP reduction was considered as a failure. RESULTS: An IOP reduction of at least 20% was achieved in 74 patients (89.1%) after 7 days and in 64 patients (86.5%) after 30 days. Sixty-two patients (74.6%) maintained IOP readings 20% lower than baseline after 60 and 90 days. In these patients, visual field indices improved in 8 eyes (13%), and remained unchanged in 54 eyes (87%). Ocular side effects were conjunctival injection (15.6%), burning sensation (9.6%), foreign body sensation (4.8%), and eyelash growth (2.4%). CONCLUSIONS: This preliminary study shows that bimatoprost 0.03% could represent a useful therapeutic tool that might defer filtration surgery.
Dr. M. Vetrungo, Department of Ophthalmology, University of Bari, Bari - Italy. m.vetrugno@oftalmo.uniba.it
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
