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Abstract #12418 Published in IGR 7-2
Optic disc topographic parameters measured in the normal cynomolgus monkey by confocal scanning laser tomography
Taniguchi T; Shimazawa M; Araie M; Tomita G; Sasaoka M; Kitazawa Y; Hara HBritish Journal of Ophthalmology 2005; 89: 1058-1062
AIM: To study optic disc topographic parameters in normal cynomolgus monkeys by Heidelberg retina tomograph (HRT). METHODS: 12 optic disc topographic parameters were investigated in 36 normal eyes in 18 male monkeys. Mean (SD) and interocular differences were obtained for each parameter from three independent measurements made during a 1 week period. Correlations among the topographic parameters were analysed, too. RESULTS: No significant differences between right and left eyes were detected for any topographic parameters. Disc area, rim area, and height variation contour showed smaller right-left differences than other parameters. The coefficients of variation for rim area, height variation contour, rim volume, mean cup depth, maximum cup depth, mean retinal nerve fibre layer (RNFL) thickness, and RNFL cross section area were less than 10% (for rim area, less than 5%). Rim area and height variation contour showed relatively weak interrelations and neither showed a correlation with disc area. CONCLUSION: For evaluating time related changes in the optic disc by HRT in monkeys, rim area and height variation contour might be useful parameters because coefficients of variation and right-left differences were lower than for other parameters and because these parameters showed weak interrelations and no correlation with disc area.
Dr. H. Hara, Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. hidehara@gifu-pu.ac.jp.
Classification:
5 Experimental glaucoma; animal models
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)