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Abstract #12602 Published in IGR 7-3
The efficacy of timolol in gel-forming solution after morning or evening dosing in Asian glaucomatous patients
Ong LB; Liza Sharmini AT; Chieng LL; Cheong MT; Vengadasalam SR; Shin HC; Balaravi PJournal of Ocular Pharmacology and Therapeutics 2005; 21: 388-394
AIMS: The aim of this study was to determine the effectiveness of timolol gel-forming solution as a monotherapy and to compare the efficacy of timolol gel-forming solution morning instillation versus at night application in Asians with newly diagnosed open-angle glaucoma. METHODS: A retrospective, comparative, parallel group study was conducted on 78 eligible patients diagnosed with open-angle glaucoma who received topical timolol gel-forming solution either on morning (AM dosing group; 39 patients) or evening (PM dosing group; 39 patients) as monotherapy treatment. Intraocular pressure was taken at baseline, 1, 3, 6, and 12 months post-treatment. RESULTS: Mean baseline intraocular pressure (IOP) for timolol gel-forming solution in general was 22.7 ± 6.6 mmHg with the mean IOP reduction of 5.7 ± 5.3 mmHg (23.1% reduction). The mean IOP reduction of the AM dosing group was 7.5 ± 5.2 mmHg (31.0% reduction) and 3.9 ± 4.9 mmHg (15.1% reduction) in the PM dosing group (P = 0.0002). There was a statistically significant difference of IOP reductions between AM and PM dosing group at 1 month (P = 0.041), 3 months (P = 0.037) and 12 months (P = 0.015) post-treatment. Seventy-five percent (24) of good responders was in the AM group and 67.4% (31) of poor responders were patients in the PM group. CONCLUSION: Timolol gel-forming solution is effective in reducing IOP in Asian eyes. Morning dosing was more effective in lowering the IOP compared to evening dosing.
Dr. L.B. Ong, Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
