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Abstract #12765 Published in IGR 7-3
Pituitary-adrenal axis system condition in patients with open angle glaucoma
Dzhodzhua T; Sumbadze TSGeorgian Medical News 2005; 9: 74-76
Our study included 71 patients (38 males and 33 females) with diagnosed open angle glaucoma and healthy 71 persons for control group. Their age ranged from 45 to 70. The patients and healthy persons were divided into three groups: group I: persons of 45-55 years old; group II: persons of 55-65 years old; group III: persons of 65-75 years old. Examination included ophthalmologic and hormonal research. To assess the function of pituitary-adrenal axis, we measured the concentrations of cortisol, aldosterone and adrenocorticotropic hormone (ACTH) in the plasma of patients and control groups by radioimmunoassay method. The level of ACTH was decreased in the females in group I and group II, and in the males of group III. The level of cortisol was increased in the males of all three groups. Aldosterone was decreased in III group of males and in I and III groups of females. According to our studies, there were some changes in secretion of these hormones as well as in their regulation. The findings confirmed the role pituitary-adrenal axis of in the regulation of IOP. In compliance to our data, the investigation of the hormonal status of patients with glaucoma is recommended for complete understanding of glaucoma etiology and pathogenesis. LA: Russian
Dr. T. Dzhodzhua, Al. Natishvili Institute of Experimental Morphology of the Academy of Sciences of Georgia, Georgia
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
