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Abstract #13056 Published in IGR 7-3
Test-retest reproducibility of optic disk deterioration detected from stereophotographs by masked graders
Parrish RK 2nd; Schiffman JC; Feuer WJ; Anderson DR; Budenz DL; Wells-Albornoz MC; Vandenbroucke R; Kass MA; Gordon MO; Ocular Hypertension Treatment Study GroupAmerican Journal of Ophthalmology 2005; 140: 762-764
See also comment(s) by Joseph Caprioli •
PURPOSE: To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS). DESIGN: Test-retest reproducibility study. METHODS: Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, re-gradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream. RESULTS: Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%. CONCLUSIONS: The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in re-grading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.
Dr. R.K. Parrish 2nd, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.20 Progression (Part of: 6 Clinical examination methods)
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
