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Abstract #13183 Published in IGR 7-3
Evaluation of the structure-function relationship in glaucoma
Gardiner SK; Johnson CA; Cioffi GAInvestigative Ophthalmology and Visual Science 2005; 46: 3712-3717
See also comment(s) by Nicholas Strouthidis & David Garway-Heath •
PURPOSE: While glaucoma is evaluated on the basis of structural and functional test results, the spatial relationship between structure and function is not well defined. This study produces a topographical map to demonstrate how sectors of the optic nerve head (ONH) are related to locations in the visual field, using empiric cross-sectional patient data. METHODS: One hundred nine subjects with healthy eyes and 166 subjects with diagnosed or suspected glaucoma (one test per patient) were evaluated using a retina tomograph and white-on-white standard automated perimetry (SAP). The tomograph ONH images were divided into 36 sectors; and the sector rim areas normalized to account for changes in the total rim area. These were then correlated with SAP thresholds. For each visual field location, a map was produced indicating the strength of correlation between the normalized sector rim areas and thresholds. RESULTS: The highest correlation between a sector's normalized rim area and a SAP location's sensitivity was 0.520. Twenty-seven of the 52 non-blind spot SAP locations exhibited a correlation greater than 0.2 with at least one ONH sector. Locations in the superior hemifield were usually best correlated with the polar inferior temporal sectors of the ONH; locations in the inferior hemifield were usually best correlated with the polar superior temporal sectors of the ONH. CONCLUSIONS: A map relating regions of the ONH to SAP test locations has been produced. This map may be useful in elucidating the structure-function relationship, particularly for cases of localized glaucomatous loss.
Dr. S.K. Gardiner, Discoveries In Sight, Devers Eye Institute, Portland, OR 97208, USA. sgardiner@discoveriesinsight.org
Classification:
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)