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Abstract #13223 Published in IGR 7-3
Clinical investigation: the intraocular pressure lowering efficacy and safety of brinzolamide combined with betaxolol
Yu M; Fang M; Ge J; Huang SEye Science 2005; 21: 137-140
PURPOSE: To evaluate the intraocular pressure (IOP) lowering efficacy and safety of Brinzolamide combined with Betaxolol for the Chinese glaucomatous patients. METHODS: Twenty- six glaucoma patients (44 eyes) diagnosed as primary open angle glaucoma, ocular hypertension and remnant glaucoma (IOP remained high after anti-glaucomatous surgeries) were recruited as a research team. After a washing out phase, Brinzolamide 1% combined with Betaxolol 0.25% were administered to them twice daily ((8 ± 1)o' clock in the morning and (20 ± 1) o'clock in the evening) respectively. The observing duration was 2 months. The IOP and the side effect before and after the administration of the eyedrops were observed. RESULTS: The average IOP lowering ranged from 5.03 mmHg to 6.65 mmHg (l mmHg = 0.133 kPa) (20.55% to 37.30%) after the administration of Brinzolamide 1% combined with Betamolol 0.25% twice a day. The IOP lowering effect was stable and the patients complained little uncomfortable. CONCLUSIONS: Brinzolamide combined with Betaxolol has significant IOP lowering effect and few side effect for the Chinese people. Brinzolamide can be used as the main medication for the treatment of glaucoma. LA: Chinese
Dr. M. Yu, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
