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Abstract #13400 Published in IGR 8-1
Resting pulse rates in a glaucoma clinic: the effect of topical and systemic β-blocker usage
Tattersall C; Vernon S; Singh REye 2006; 20: 221-225
INTRODUCTION: Beta-blockers have, for 25 years, been a commonly used agent in the treatment of raised intraocular pressure (IOP). Beta-blockers can also reduce the pulse rate. With no available literature examining a cohort of patients, this study aims to investigate the resting pulse rates in patients attending a specialist glaucoma clinic in order to identify if routine review of ophthalmic medication use is indicated. METHOD: The resting pulse rates of patients attending a glaucoma clinic were measured using pulseoximetry, with a medical and drug history established for each patient. RESULTS: In all, 205 patients were included in the study. A total of 101 (49%) of patients were using β-blockers in some form. The mean pulse rate for patients not using β-blockers (104 patients) was 76 beats per minute (bpm), for topical use only (68 patients) it was 70.3 bpm, for oral use (18 patients) it was 64.7 bpm, and 58 bpm for patients using both topical and oral β-blockers (15 patients). Groups using β-blockers (oral, topical, oral and topical) were considered in relation to patients not using β-blockers. All groups using β-blockers showed a significant association with causing a bradycardia of less than 60 bpm. Patients with a pulse rate of less than 50 bpm were significantly more likely to be using topical and oral β-blockers than oral β-blockers alone (P = 0.01). CONCLUSION: Topical β-blockers should be used with caution, even in the presence of established systemic β-blocker use. Routine pulse rate monitoring and review of ophthalmic medication are indicated in patients using β-blocker therapy.
Dr. C. Tattersall, Department of Ophthalmology, Queens Medical Centre, NHS trust, Nottingham, UK. chris.tattersall@mail.qmcuh-tr.trent.nhs.uk
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
