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Abstract #13425 Published in IGR 8-1
Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma
Ugahary LC; Ganteris E; Veckeneer M; Cohen AC; Jansen J; Mulder PG; van Meurs JCAmerican Journal of Ophthalmology 2006; 141: 571-573
PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma. DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study. METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart. RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mmHg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo. CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.
Dr. L.C. Ugahary, The Rotterdam Eye Hospital, Rotterdam, The Netherlands
Classification:
11.3 Adrenergic drugs (Part of: 11 Medical treatment)
