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Abstract #13513 Published in IGR 8-1
Observational survey on the use of dual therapy in ocular hypertension or glaucoma treatment
Bron A; Nordmann JP; Rouland JF; Baudouin C; Sartral MJournal Français d'Ophtalmologie 2006; 29: 164-168
AIM: To ascertain why ophthalmologists shift therapy to a fixed-combination or non-fixed-combination drug therapy. PATIENTS AND METHODS: A prospective multicenter observational study was conducted among French ophthalmologists working in private or mixed practice. The study included adult patients with open-angle glaucoma or ocular hypertension, treated with monotherapy or dual therapy and needing to modify their initial treatment. The patients had to fill out a self-questionnaire 15 days after the change in therapy, evaluating the compliance and assessment of the new treatment. RESULTS: The analysis was made on 775 questionnaires filled out by ophthalmologists between March 1st and July 31st 2003 on 5734 patients. The mean age was 66.4 ± 12.4 years and women represented 53.6% of the patients. The diagnosis had been made, on average, 7.5 ± 7.3 years before. The mean initial intraocular pressure under treatment was 19.8 ± 4.1 mmHg in both eyes. Initially, 58.2% of the patients had monotherapy, 40.4% dual therapy and 1.4% triple therapy. The main reasons for shifting therapy were 'high intraocular pressure under treatment' for 63.5% of the patients and 'simplification of the treatment' for 39.1% of the patients (several reasons per patient were accepted). Most of the patients were satisfied with their new therapy (71%), which in most cases was a fixed-combination therapy (95.2%). DISCUSSION: This study has shown that the use of at least two active principles is a common practice in the treatment of glaucoma and ocular hypertension. An additive therapy is given in order to better control the intraocular pressure, mainly with a fixed combination. LA: French
Dr. A. Bron, Service d'Ophtalmologie, CHU, Dijon, France
Classification:
11.1 General management, indication (Part of: 11 Medical treatment)
