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Abstract #13565 Published in IGR 8-2
The optic nerve: A new window into cerebrospinal fluid composition?
Killer HE; Jaggi GP; Flammer J; Miller NR; Huber ARBrain 2006; 129: 1027-1030
See also comment(s) by Jost Jonas •
Cerebrospinal fluid (CSF) pressure and composition are generally thought to be homogeneous within small limits throughout all CSF compartments. CSF sampled during lumbar puncture therefore should be representative for all CSF compartments. On the basis of clinical findings, histology and biochemical markers, we present for the first time strong evidence that the subarachnoid spaces (SAS) of the optic nerve (ON) can become separated from other CSF compartments in certain ON disorders, thus leading to an ON sheath compartment syndrome. This may result in an abnormal concentration gradient of CSF molecular markers determined in locally sampled CSF compared with CSF taken during lumbar puncture.
Dr. H.E. Killer, Kantonsspital Aarau, CH-5001 Aarau, Switzerland
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
