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Abstract #13924 Published in IGR 8-2
Long-term follow-up of initial trabeculectomy with mitomycin C for primary open-angle glaucoma in Japanese patients
Shigeeda T; Tomidokoro A; Chen YN; Shirato S; Araie MJournal of Glaucoma 2006; 15: 195-199
PURPOSE: To determine the long-term intraocular pressure (IOP) control and postoperative complications after initial trabeculectomy with use of mitomycin C (MMC) in patients with primary open-angle glaucoma (POAG). PATIENTS AND METHODS: A retrospective review was conducted of a consecutive series of 123 eyes (87 patients) with POAG who underwent initial trabeculectomy with MMC and had at least 4 years of follow-up. All patients underwent standard trabeculectomy with 0.04% MMC applied intraoperatively for 3 minutes. The long-term outcomes (IOP control and bleb leak, long-standing hypotony, bleb-related infections) were analyzed with the Kaplan-Meier life-table method on the basis of three definitions of successful IOP control (defined as IOP < 18 mmHg (definition 1), IOP < 16 mmHg (definition 2), and IOP decrease of by ≥ 30% and < 21 mmHg (definition 3)). RESULTS: The mean follow-up time was 6.8 ± 1.4 (mean ± SD) years. The cumulative survival rates were 67.0 ± 4.6%, 44.5 ± 5.4%, and 74.1 ± 4.2%, respectively, based on definitions 1, 2, and 3, 8 years postoperatively by life-table analysis. At 8 years, bleb leak occurred in 7.9 ± 2.6% of eyes, long-standing hypotony in 8.3 ± 2.5%, and bleb-related infections in 5.9 ± 2.4%. CONCLUSION: Long-term outcome after initial trabeculectomy with MMC in Japanese POAG patients is comparable with that reported in other populations and with that after trabeculectomy with 5-fluorouracil.
Dr. T. Shigeeda, Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)