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Abstract #13955 Published in IGR 8-3
Retrobulbar haemodynamics and contrast sensitivity improvements after CO2 breathing
Huber KK; Adams H; Remky A; Arend KOActa Ophthalmologica Scandinavica 2006; 84: 481-487
PURPOSE: Effects of gas mixtures have been widely studied. Carbon dioxide (CO2 ) is known to act as a vasodilator, whereas oxygen (O2 ) acts as a vasoconstrictor. Therefore, the interpretation of results is difficult. In this study, only the effect of an elevated CO2 level on retrobulbar hemodynamics and contrast sensitivity was investigated. METHODS: Thirty adults (age 31 ± 7) were examined under normocapnic and hypercapnic conditions. Colour Doppler imaging was used to measure the velocity in the ophthalmic and central retinal artery. Moreover, contrast sensitivity using the CSV-1000 was investigated. Blood pressure, heart rate and intraocular pressure (IOP) were measured and ocular perfusion was calculated. RESULTS: Under hypercapnia, mean end tidal CO2 increased from 36.4 mmHg to 42.5 mmHg and blood oxygen saturation increased from 98.3% to 98.6% (p < 0.0001). Hypercapnia significantly reduced IOP by 0.94 mmHg (p < 0.0008). In the central retinal artery, the mean PSV increased by 18% (p < 0.0001) and the mean EDV by 21% (p = 0.0054). In the ophthalmic artery, the mean PSV increased by 13% (p < 0.0001) and the mean EDV by 26% (p = 0.0002). Furthermore, there was a significant increase of contrast sensitivity (spatial frequency: 3cpd: p = 0.0016; 6cpd: p = 0.005; 12cpd: p = 0.0012). Systolic blood pressure (p = 0.0225), mean arterial blood pressure (p = 0.0097) and ocular perfusion pressure (p = 0.0013) increased significantly. CONCLUSION: This setting was able to detect an increase in blood flow velocity in normal subjects under hypercapnia. Furthermore, hypercapnia results in a functional improvement in contrast sensitivity, possible due to the increased blood flow or the increase in blood oxygen levels.
Dr. H.K Huber, Department of Ophthalmology, Rheinisch Westfaelische Technische Hochschule Aachen University, Germany. khuber@ukaachen.de
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
