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Abstract #13957 Published in IGR 8-3
Esterified estrogens combined with methyltestosterone raise intraocular pressure in postmenopausal women
Khurana RN; Labree LD; Scott G; Smith RE; Yiu SCAmerican Journal of Ophthalmology 2006; 142: 494-495
PURPOSE: To investigate the effect of esterified estrogens combined with methyltestosterone (EECM) (Estratest, Solvay, Pharmaceuticals, Inc, Baudette, Minnesota, USA) on intraocular pressure (IOP) in postmenopausal women. DESIGN: Observational case series. METHODS: The IOP of 13 consecutive postmenopausal women with dry eye syndrome were recorded before and during EECM therapy (1.25 mg of esterified estrogens and 2.5 mg of methyltestosterone for several months). RESULTS: The mean IOP increased from a baseline of 15.0 mmHg before treatment to 18.2 mmHg on EECM therapy (P < .0001) after a median duration of 11.3 months (range, 0.9 to 24 months). The increase in IOP was statistically significant at the 0.05 level of significance within three months and continued over 12 months. Two patients whose pressures increased ( > 4 mmHg) returned to baseline levels after EECM was discontinued. CONCLUSIONS: Esterified estrogens combined with methyltestosterone produce a clinically significant increase in IOP in postmenopausal women with dry eye syndrome.
Dr. R.N. Khurana. Ocular Surface Center, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Classification:
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
