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Abstract #14180 Published in IGR 8-3
Subconjunctival placement of human amniotic membrane during high risk glaucoma filtration surgery
Bruno CA; Eisengart JA; Radenbaugh PA; Moroi SEOphthalmic Surgery Lasers and Imaging 2006; 37: 190-197
BACKGROUND AND OBJECTIVE: To determine whether subconjunctival placement of amniotic membrane improves filtration results in patients with glaucoma at high risk for surgical failure. PATIENTS AND METHODS: Retrospective review of 17 eyes of 15 patients who had amniotic membrane applied during glaucoma surgery with or without mitomycin C or 5-fluorouracil. RESULTS: Mean intraocular pressure decreased from 27.0 ± 9.1 mmHg preoperatively to 18.1 ± 11.0 mmHg postoperatively with a mean follow-up of 179 days. Complications included self-limited conjunctival wound dehiscence (n = 5), uveitis recurrence (n = 2), and cataract progression (n = 1). CONCLUSIONS: The results suggest that subconjunctival placement of amniotic membrane may improve filtration outcome in high risk eyes. It will be of interest to determine whether the anti-inflammatory, anti-angiogenic, and antifibrotic properties of amniotic membrane placed subconjunctivally and under the scleral flap will improve filtration surgery outcome by a prospective, randomized study.
Dr. C.A. Bruno, University of Michigan, Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, 1000 Wall St., Ann Arbor, MI 48105, USA
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
