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Abstract #14217 Published in IGR 8-3

Ultrastructural changes of vascular endothelium cell in optic nerve with diabetic neovascular glaucoma

Chen S; Xia Y; Jiang T; Jiang Z; Jiang S
Chinese Ophthalmic Research 2006; 24: 203-205

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OBJECTIVE: Diabetic neovascular glaucoma is a serious complication of the diabetes mellitus when rubeosis irdis occurs and is difficult to treat. This study was curried out to observe the ultrastructural changes of vascular endothelium cells in optic nerve with diabetic neovascular glaucoma under transmission electron microscope (TEM) and analyze the meaning of the changes. METHODS: Six cases with diabetic neovescular glaucoma were treated with ophthalmectomy from January 2000 to June 2004 in Nanjing General Hospital of Nanjing Command PLA. The optic nerve was excised 2 mm post eyeball in these patients and fixed by the glutaral for the examination of TEM (JEM-1200EX). RESULTS: The ultrastructure of vascular endothelium in optic nerve was altered by diabetic neovascular glaucoma, including the decrease of villi of the endothelial cell in capillary vessel and cell apoptosis and cleavage. Some endothelial cell necrosis and loss, vascular cavity stricture, venulae endothelium swelling, vacuole degeneration, elastic fibers swelling and twisting could be seen in cytoplasm, and the vascular cavity was very stricture in the specimen. Some new thrombosis of vascular cavity was connected with the basal membrane of vessel. CONCLUSION: The ultrastructural changes of the vascular endothelium cells might be one of the pathogenesis bases of the irreversibility optic function damage in the diabetic neovescular glaucoma. LA: Chinese

Dr. S. Chen, Department of Ophthalmology, Nanjing General Hospital of Nanjing Command PLA, Clinical School of Medical College of Nanjing University, Nanjing 210002, China

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Classification:

9.4.5.1 Neovascular glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)

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