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1 General aspects (0)   1.1 Epidemiology (7)   1.2 Population genetics (1)   1.3 Pathogenesis (3)   1.4 Quality of life (5)   1.5 Glaucomas as cause of blindness (1)   1.6 Prevention and screening (1) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (2)   2.2 Cornea (7)   2.3 Sclera (0)   2.4 Anterior chamber angle (0)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (7)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (1)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (2)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (2)   2.9 Ciliary body (0)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (2)   2.13 Retina and retinal nerve fibre layer (16)   2.14 Optic disc (7)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (0)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (7)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (16)     3.4.2 Gene studies (3)   3.5 Molecular biology incl. 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Abstract #14236 Published in IGR 8-3

Effect of TNF-α on MMP₃, MMP₉ and TIMP-2 expression in cultured bovine trabecular cells

Wu Q; Zhang D-X; Li C; Qi X-Y
International Journal of Ophthalmology 2006; 6: 328-331

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AIM: To study the effect of tumor necrosis factor-α (TNF-α) on the expression of matrix metalloproteinases (MMPs) in the cultured bovine trabecular cells (BTCs) and approach to pathogenesis and mechanism of primary open angle glaucoma (POAG). METHODS: BTCs were primarily cultured and subcultured. The third passage cells were incubated with different dosages of TNF-α (0, 12.5, 25 and 50μ g/L, final concentration, diluted by DMEM) for 48h. MMP₃ and MMP₉ were determined by immunohistochemistry method. The results were analyzed by the computer image-analysis system and statistical test. Levels of TIMP-2 in cell media were quantified by ELASA. RESULTS: The cultured BTCs expressed MMP3 and MMP9. In comparison with the control group, TNF-α increased the expression of MMP₃ and MMP₉ , but decreased TIMP-2 expression in BTCs. CONCLUSION: To a certain extent, TNF-α can decrease the stacking in ECM and the resistance of aqueous outflow in trabecular meshwork. LA: Chinese

Dr. D.-X. Zhang, Department of Ophthalmology, Hospital of Xi'an Jiaotong University, Xi'an 710061 Shaanxi Province, China

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Classification:

2.5.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.5 Meshwork)
3.3 Immunohistochemistry (Part of: 3 Laboratory methods)
5 Experimental glaucoma; animal models

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