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Abstract #14489 Published in IGR 8-4
The effect of glycine with timoptol on the rabbit IOP physiological values
Veselovsky J; Olah Z; Vesela A; Gressnerova SČeska a Slovenska Oftalmologie 2006; 62: 247-254
PURPOSE: the mixture of 10% L-glycine.HCl in 0.5% Timoptol, intensity and duration of effect on the physiological IOP is evaluated in this work. METHODS: Experiments were performed on 5 rabbits of the New Zealand White species. The mixture and its components were individually instilled into the left conjunctival sac. The right eye was used as control. RESULTS: after instillation of the 10% L-glycine.HCl and 0.5% Timoptol mixture the IOP showed significant decrease compared with the control eye during 24 hour evaluation. Maximal decrease for 33% (8.5 torr) was measured in 60th min., compared with the decrease for 30.5% (7.6 torr) in 120th and for 28% in 30th min. On the contrary, both substances alone - the 10% L-glycine.HCl and 0.5% Timoptol decrease the physiological IOP values only no significantly compared with their mixture and the control eyes. The mean value of the pupilar diameter was 7.8 mm on both eyes. CONCLUSIONS: We assume that the decrease of the physiological IOP value is caused by a new metabolite - the 'bioantiglaucomatic' created by interaction of glycine and Timoptol in vitro. The effect of this mixture on the decrease of the physiological IOP values is 8-times stronger compared with Timoptol and 4.3-times stronger compared with glycine. Application of such already prepared bioantiglaucomatic in the clinical practice can contribute to the more effective, safe and reliable therapeutic effect on the IOP in glaucomatic disease. LA: Slovak
Dr. J. Veselovsky, Katedra Zivocisnej Fyziologie a Etologie, PriF UK, Mlynska dolina B/2, 842 15 Bratislava, SR, Slovak Republic
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
5 Experimental glaucoma; animal models