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Abstract #15499 Published in IGR 1-3
Pharmacological profile of a new topical pilocarpine formulation
Bucolo C; Mangiafico PJournal of Ocular Pharmacology and Therapeutics 1999; 15: 567-773
A new formulation based on pilocarpine hyaluronate salt has been shown to improve the bioavailability of the drug and to extend the duration of activity. The authors evaluated the extent of intraocular pressure reduction, duration of action, and kinetics of miotic response of this formulation in comparison with a commercial preparation with the same drug concentration. Ocular hypertension in the rabbit was induced by α-chymotrypsin or by water loading. The hypotensive effect of the new formulation treatment was significantly greater and longer than that observed in rabbit eyes treated with the commercial preparation both in the normotensive and in the hypertensive animals. Furthermore, the authors evaluated the miotic response in normotensive rabbits showing a greater miotic response and an extended duration when the eyes were treated with the new formulation. The pharmacological profile of the new formulation described in this study indicates an increase of efficacy and duration of action compared to the commercial preparation.
Dr. C. Bucolo, Fidia Oftal Research Laboratories, Catania; Italy
Classification:
11.2 Cholinergic drugs (Part of: 11 Medical treatment)
