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Abstract #15510 Published in IGR 1-3
Comparison of 24 hour control with Timoptic(TM) 0.5% and Timoptic-XE(TM) 0.5% in exfoliation and primary open-angle glaucoma
Konstas AGP; Mantziris DA; Maltezos A; Cate EA; Stewart WCActa Ophthalmologica Scandinavica 1999; 77: 541-543
PURPOSE: To compare the 24-hour intraocular pressure (IOP) curve in exfoliation glaucoma (EXG) and primary open-angle glaucoma (POAG) patients treated first with timolol solution 0.5% (TS) twice daily and then with timolol maleate gel forming solution 0.5% (TXE) once daily. METHODS: The authors prospectively investigated age-matched, newly diagnosed EXG (n=25) and POAG (n=25) patients who were admitted as inpatients for 24-hour phasing, first with TS and then TXE. RESULTS: Generally, TS and TXE controlled both POAG and EXG patients in a similar fashion. However, a trend to lower pressures was observed in both EXG and POAG patients with TS therapy. At two time points (10:00 and 22:00) in POAG patients, TS (18.4±3.7 and 17.2±3.1 mmHg, respectively) provided lower intraocular pressures than TXE (19.8±3.5 and 18.9±3.8 mmHg, respectively) (p < 0.05). CONCLUSION: Both TS twice daily and TXE once daily control POAG and EXG generally to a similar extent.
Dr. W.C. Stewart, Pharmaceutical Research Corporation, 1639 Tatum Street, Charleston, SC 29412-3464; USA
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)