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The purpose of this study was to characterize the ocular pharmacokinetics of a beta blocker, tilisolol, after instillation into anesthetized rabbits using a mathematical model including a diffusion process. The samples were analyzed by HPLC. Anesthetized rabbit was used as a model of tear secretion deficiency. Anesthetized rabbits showed higher drug concentration in the tear fluid and aqueous humor after instillation than unanesthetized rabbits. A mathematical model including a diffusion process and in vivo penetration parameters well described the concentrations of tilisolol in the aqueous humor after instillation in anesthetized rabbits.
Dr. H. Sasaki, Department of Hospital Pharmacy, Nagasaki University School of Medicine, Nagasaki; Japan
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)