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Abstract #15517 Published in IGR 1-3
Latanoprost may trigger the biosynthesis of endogenous prostaglandins in early postoperative pseudophakias (letter)
Camras CBArchives of Ophthalmology 1999; 117: 1265-6
in this letter to the editor the corresponding author comments on a paper by Miyake et al. in Archives of Ophthalmology 1999; 117: 34-40: Latanoprost accelerates disruption of the blood-aqueous barrier and the incidence of angiographic cystoid macular edema in early postoperative pseudophakias. The original authors found perifoveal leakage of fluoresceine 5 weeks after cataract surgery and Latanoprost use. The comment is the following. Clinical cystoid macular edema did not occur. No differences in visual acuities were found. Despite continuous treatment with Latanoprost for 5 weeks the flare respons returned to control values. The magnitude of the flare at 1 week was relatively small. Simultaneous treatment with Diclofenac-sodium failed to show leakage. This means that Latanoprost itself was not responsible for the leakage. Diclofenac did not affect the Latanoprost induced reduction of intra-ocular pressure. The point is that Diclofenac and other non-steroidal anti-inflammatory drugs inhibit endogeneous synthases of PG's. it is known that Latanoprost may stimulate the production of other PG's in ocular tissues. Latanoprost itself is not known to be vaso-active or to affect vascular permeability. It is of clinical interest that Latanoprost may be safer used with a non-steroidal anti-inflammatory drug after cataract extraction. Furthermore it would certainly be of interest to compare the effect of Latanoprost with other glaucoma medications in a similar protocol. The original authors agree with the comment.
Omaha, Nebraska
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
