advertisement
Abstract #15538 Published in IGR 1-3
Effect of topical amosulalol on tissue circulation in the optic nerve head
Tamaki Y; Araie M; Muta KJournal of Ocular Pharmacology and Therapeutics 1999; 15: 217-224
The effect of topical 0.1% amosulalol on tissue circulation in the albino rabbit optic nerve head (ONH) was investigated using a laser speckle tissue circulation analyzer. Amosulalol was administered into one eye twice daily for 20 days, and vehicle was administered into the other eye in a masked, randomized manner. Intraocular pressure (IOP) was measured every five days. The normalized blur value (NB), a quantitative index of tissue blood flow velocity in the ONH, was measured before treatment and two hours after the last instillation on day 20. The IOP was also measured at five-day intervals. Amosulalol decreased IOP by approximately 2 mmHg in the treated eyes (p < 0.01). There was no significant difference in NB between eyes before the first instillation, whereas NB was significantly greater (by approximately 16%) in the amosulalol-treated eye than in the control eye after completion of instillations (p < 0.01). The difference between NB after completion of instillations and that before the first instillation was significantly greater in the ONH of the amosulalol-treated eye than in the contralateral control eye (p < 0.01). Twice-daily instillation of 0.1% amosulalol for 20 days induced a significant increase in tissue blood velocity in the ipsilateral ONH in albino rabbits.
Dr. Y. Tamaki, Eye Clinic, Tokyo Metropolitan Geriatric Hospital, Tokyo; Japan
Classification:
11.7 Treatment of bloodflow (Part of: 11 Medical treatment)
