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Abstract #15666 Published in IGR 2-3
A comparison of dorzolamide-timolol combination versus the concomitant drugs
Choudhri S; Wand M; Shields MBAmerican Journal of Ophthalmology 2000; 130: 832-833
PURPOSE: To compare the intraocular pressure (IOP) lowering effect of fixed combination dorzolamide 2% and timolol 0.5% therapy to that of concomitant administration of a topical beta-blocker and dorzolamide. METHODS: Seventy-four consecutive glaucoma patients were changed from a regimen including a topical beta-blocker and dorzolamide to the fixed combination dorzolamide-timolol in one eye, with the other eye used as the control. The average IOP readings before and one month after the change were compared. RESULTS: The mean baseline IOP in the entire study population was 19.4 ± 4.2 mmHg in the study eyes and 16.9 ± 4.2 mmHg in the control eyes. Four weeks after the medication change, the mean IOP was 17.3 ± 3.9 mmHg in the study eyes (p < 0.001) and 16.1 ± 4.1 mmHg in the control eyes (p = 0.02). The difference between the mean IOP change of 2.1 mmHg in the study eyes and 0.8 mmHg in the control eyes was found to be statistically significant (p = 0.01). CONCLUSIONS: These findings suggest that the fixed combination dorzolamide-timolol therapy achieves additional lowering of the intraocular pressure compared with the concomitant administration of a beta blocker and dorzolamide.
Dr. S. Choudhri, Yale University School of Medicine, New Haven, CN, USA
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
