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Abstract #15878 Published in IGR 2-3
The effect of latanoprost on aqueous humor PGF2α levels in glaucoma patients
Güven D; Karakurt A; Saban E; Hasiripi HInternational Ophthalmology 1999; 23: 91-96
AIM: The purpose of this study was to evaluate the effect of the PGF2α isopropyl ester analogue, latanoprost, which is a new ocular hypotensive topical agent, on the aqueous humor PGF2α levels in open-angle glaucoma patients. METHODS: Patients diagnosed with either capsular or primary open-angle glaucoma and scheduled for trabeculectomy, were consecutively enrolled in the study. Group 1 was the control group (n = 17) and group 2 the latanoprost treatment group (n = 9). All topical drugs were stopped ten days preoperatively and only systemic carbonic anhydrase inhibitor were continued if necessary. Group 2 patients received topical 0.005% latanoprost once daily for five to ten days preoperatively. During trabeculectomy operation, aqueous samples were taken from the patients by paracentesis. Aqueous humor levels of PGF2α and its metabolite 13,14-dihydro-15-keto-PGF2α were measured using enzyme immunoassay. RESULTS: The mean PGF2α levels were 24.38 ± 5.79 pg/m. in the control group and 10.99 ± 4.11 pg/ml in the latanoprost group, the difference being statistically significant (p < 0.05). In the latanoprost group, there was a positive correlation between levels of PGF2α and its metabolite (p < 0.05). CONCLUSIONS: Pretreatment with the PGF2α isopropyl ester analogue, latanoprost, topically decreased PGF2α levels in the aqueous humor of glaucomatous eyes, probably due to its uveoscleral outflow increasing effect. The clinical importance and application of this result still has to be determined.
Dr. D. Güven, Ankara Numune Hospital, 3rd Eye Clinic, Ankara, Turkey
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
