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Abstract #15902 Published in IGR 2-3
Bioavailability of antiglaucoma drugs
Demailly PJournal Français d'Ophtalmologie 2000; 23: 518-522,523
The bioavailability of antiglaucoma drugs, generally delivered in an aqueous eye-drop solution, depends on their capacity to cross the cornea. The structure of the cornea forms a barrier to strongly lipophilic substances and the continuous renewal of the lacrimal film creates a major obstacle, preventing active substances from penetrating the eye. Active substances must thus be delivered in highly concentrated solutions. The systemic bioavailability of antiglaucoma drugs taken orally, for example beta blockers, is well known, while their behavior after eye-drop administration remains poorly elucidated and highly dependent on individual susceptibility. The authors reviewed the literature regarding pilocarpine, beta blockers, adrenergic drugs (dipivalyl-epinephrine, apraclonidine, brimonidine), carbon anhydrase inhibitors (acetazolamide, dorzolamide).LA: French
Classification:
11.1 General management, indication (Part of: 11 Medical treatment)
