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Abstract #15912 Published in IGR 2-3
The effect of propofol and alfentanil on the increase in intraocular pressure due to succinylcholine and intubation
Eti Z; Yayci A; Umuroglu T; Goegues FY; Bozkurt NEuropean Journal of Ophthalmology 2000; 10: 105-109
PURPOSE: The aim of this study was to evaluate the effects of propofol and alfentanil on the increase in intraocular pressure (IOP) due to succinylcholine and intubation, in comparison with thiopental sodium and vecuronium bromide. METHODS: Forty patients aged 20-50 years, scheduled for elective surgery requiring endotracheal intubation, were assigned to four groups of ten. General anesthesia was induced with 2.5 mg/kg propofol in Group 1, 2.5 mg/kg propofol and 10 μg/kg alfentanil in Group 2 and 5 mg/kg thiopental in Groups 3 and 4; muscle relaxation was obtained with either 1.5 mg/kg succinylcholine (Groups 1, 2, and 3) or 0.1 mg/kg vecuronium bromide (Group 4). In all patients mean arterial pressure, heart rate, oxygen saturation and IOP were recorded before (baseline) and after induction, after the muscle relaxant and after endotracheal intubation. RESULTS: Compared with their baseline values in Group 1, IOP decreased significantly after propofol (p < 0.01) and increased significantly after intubation (p < 0.01). In Group 2, IOP decreased significantly after propofol and alfentanyl (p < 0.001), remained low after succinylcholine (p < 0.01) and did not change after intubation. In Group 3, IOP decreased significantly after thiopental (p < 0.001) and increased significantly after intubation (p < 0.001). In Group 4, it decreased significantly after thiopental (p < 0.001), remained low after vecuronium (p < 0.001) and increased significantly after intubation (p < 0.05). CONCLUSIONS: In none of the Groups did IOP increase significantly after succinylcholine, but only anesthesia induced with propofol and alfentanil prevented the increase in IOP due to intubation.
Dr. Z. Eti, Department of Anesthesia and Reanimation, Medical Faculty of Marmara University, Istanbul, Turkey
Classification:
12.17 Anesthesia (Part of: 12 Surgical treatment)
