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Abstract #15913 Published in IGR 2-3
Effect of topically applied iganidipine dihydrochloride, a novel Ca2+ antagonist, on optic nerve head circulation in rabbits
Waki M; Sugiyama T; Watanabe N; Ogawa T; Shirahase H; Azuma INippon Ganka Gakkai Zasshi 2000; 104: 541-546
PURPOSE: The authors studied the effect of topically applied iganidipine dihydrochloride, a novel water-soluble calcium channel blocker on the blood flow of optic nerve head (ONH), intraocular pressure, and blood pressure in rabbits. METHODS: 0.1% iganidipine (20 μl) was instilled into a normal eye. The change in blood flow in the ONH was measured using a hydrogen gas clearance flowmeter. Iganidipine (0.0001%-0.1%) was instilled into a circulation-disordered eye before or after the intravitreal injection of endothelin-1, and change in the blood flow in the ONH was measured. Changes in intraocular pressure and blood pressure after instillation of 0.1% iganidipine were measured. In all experiments, physiological saline was instilled in each contralateral eye as a control. RESULTS: Instillation of iganidipine significantly increased the blood flow in the ONH by 40% at 45 minutes after instillation. Pre-instillation of 0.01 and 0.1% iganidipine almost completely inhibited the decrease of blood flow in the ONH in the circulation-disordered model. The decrease of blood flow in the ONH was corrected with post-instillation of 0.1% iganidipine. These effects were continuous. Instillation of 0.1% iganidipine did not change either intraocular pressure or blood pressure. CONCLUSIONS: It was shown that instillation of iganidipine continuously increased and maintained the blood flow in the ONH in normal and circulation-disordered rabbit eye models.LA: Japanese
Dr. M. Waki, Research Laboratories, Senju Pharmaceutical Co. Ltd., Kobe, Japan
Classification:
11.7 Treatment of bloodflow (Part of: 11 Medical treatment)
