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Abstract #15969 Published in IGR 2-3
Brimonidine tartarate 0,2% (Alphagan) associated granulomatous anterior uveitis
Goyal R; Raghu Ram AREye 2000; 14: 908-810
This is a report of a 73 years old woman with ocular hypertension for 3 years who received betaxolol and pilocarpine in both eyes. Because of pressures of 30 mmHg, pilocarpine was changed to brimonidine twice daily. Six months later the patient presented with redness and blurring of vision. A diagnosis of bilateral anterior uveitis was made and she was treated with topical dexamethasone. The condition resolved uneventfully. However the uveitis recurred after stopping topical steroids. Brimonidine was discontinued and the disease subsided. There was complete resolution in two weeks. Brimonidine rechallenge was performed in the other eye after obtained informed consent. She immediately developed the disease again. This seems to be the first observation of anterior uveitis being associated with brimonidine. The authors discuss the possible mechanism.
Department of Ophthalmology, Royal Glamorgan Hosptial, Ynysmaerdy, South Wales CF72 8XR, UK
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
