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Abstract #15985 Published in IGR 2-3
Measurement of human retinal thickness at the posterior pole with a retinal thickness analyzer in normal and glaucomatous eyes
Yang Z; Du SChinese Journal of Ophthalmology 2000; 36: 124
OBJECTIVE: To determine the diagnostic value of a retinal thickness analyzer (RTA) in glaucoma. METHODS: An RTA was used to measure retinal thickness at the posterior pole in 77 normal persons (116 eyes) of various ages, and 22 cases (35 eyes) with glaucoma. The images obtained were processed by a computer to yield the retinal thickness value and the thickness map at this location, and the data were analyzed with an SAS software package. RESULTS: The mean retinal thickness of normal subjects was 171.83 ± 18.50 μm, with no significant different among the various age groups (f = 2.68, p > 0.05), but very significant between the sexes; the thickest retina was at the point between the macula and optic nerve head, and the macular nasal retina was 11.7% thicker than on its temporal side. The upper and lower foveal retinas were basically symmetrical. The retinal thickness in glaucoma patients showed diffuse or local thinning, and there was a very significant difference between that of the normal group and that of the glaucoma group (f = 11.98, p = 0.0001). The sensitivity rate for detecting glaucoma with an RTA was up to 80.8%, with specificity of up to 78.5%. CONCLUSIONS: The thickness map for the retina at the posterior pole across the macula in normal subjects is 'horseshoe' shaped, i.e., well-matched with the topography of retinal ganglion cells and retinal nerve fibers in the human retina. Diffuse or local thinning of retinal thickness in glaucoma patients, which is in agreement with the corresponding visual field defect, and the sensitivity of the RTA, is higher than that of the perimeter. The RTA examination is easy to carry out, has high reproducibility, is not invasive, and is therefore an ideal method for measuring human retinal thickness in vivo.LA: Chinese
Dr. Z. Yang, Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China. zhikuonyang@163.net
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.5 Other (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
